Take the Felizzano exit from the Torino-Piacenza highway (A-21),
then follow the signs to Alessandria.
At the Felizzano traffic light turn left towards Fubine. After passing through Fubine, follow the signs to Vignale.
At the intersection at the top of a hill, do not turn right for Vignale, but continue in the direction of Casale.
After rounding a curve at the bottom of the hill, turn left for Frassinello.
Pass through Frassinello following the directions for Casale. Almost at the bottom of this valley turn left for Sala Monferrato.
Cascina Valpane (you will see a small tower surrounded by cedars and a field with two wells) is on the right, 500 m before the Campo Sportivo-Frazione Coppi (sports grounds), near the sign for the nearest Carabinieri station.
The street up to the estate ends in a paved driveway flanked at the entrance by rosebushes and two old granite columns with VALPANE written on them.